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中科院昆明动物研究所导师介绍:徐林

 

  科学家们普遍认为突触可塑性是研究学习记忆的最佳细胞分子模型。30多年来的研究进展已充分证明突触可塑性参与了记忆的获取、巩固和提取。学习记忆涉及到大脑的许多区域和许多细胞分子过程,而突触可塑性是其中一部分,并不等于学习记忆。通俗地认为是学习记忆过程留下的痕迹。至今,突触可塑性是如何参与学习记忆仍然是个谜。许多工作需要系统地研究,如:突触可塑性是否可以传递?突触可塑性是如何参与应激、毒品成瘾等异常记忆?神经信息编码与突触可塑性的关系?这些内容也是本实验室研究的课题,如:国家杰出青年基金(突触可塑性在应激导致的大脑衰老中的作用)、科学院重要方向(心理依赖性与突触可塑性)。

  近年来发表的科研论文:

  1. Wenyong Xiong a, c, Yuexiong Yang a, Jun Cao a, Huiming Wei b, Chongli Liang b, Shangchuan Yang a, Lin Xu a* (2003) The stress experience dependent long-term depression disassociated with stress effect on spatial memory task. Neuroscience Research 46(4): 415-421 [IF=1.77]

  2. Yuexiong Yang 1, Jun Cao 1, Wenyong Xiong 1, Jichuan Zhang 1, Qixin Zhou 1, Huiming Wei 2, Chongli Liang 2, Jianhua Deng 3, Tianfei Li 3, Shangchuan Yang 1, and Lin Xu1 * (2003) Both Stress Experience and Age Determined the Impairment or Enhancement Effect of Stress on Spatial Memory Retrieval. Journal of Endocriology 178(1): 45-54 [IF=2.832]

  3. Ya Yang1 *, Xigeng Zheng 2*, Yongfu Wang 3, Jun Cao 1, Zhifang Dong 1, Jingxia Cai 3, Nan Sui 2, Lin Xu 1 (2003) The Synergistic Action of Stress and Morphine Induced large Long-term Depression in the CA1 Area of the Hippocampus of Anesthetized Rats and Long-term Effect on Drug Seeking Behavior. Journal of Neuroscience (revised) [IF=8.99]

  4. Yuexiong Yang a, Yueming Mab *, Linxian Ni b, Shengquan Zhao b, Lijun Li b, Jianyin Zhang b, Mao Fan b, Huiming Wei c, Chongli Liang c, Jun Cao a, Lin Xua * (2003) Lead Exposure Through Gestation-only Caused Lower Sex Ratio of Male at Birth and Long-term Memory Deficits in Young Adult Offspring. Experimental Neurology (in press) [IF=3.5]

  5. Huiming Wei; Wenyong Xiong; Shangchuan Yang; Qixin Zhou; Chongli Liang; BangXiong Zeng; Lin Xu (2002) Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats. Neuroscience Letters, 324(3): 181-184. [IF=2.02]

  6. Lin Xu; Anwyl R; Rowan MJ (1998) Spatial exploration induces a reversal of long-term potentiation in rat hippocampus. Nature, 394: 891-894. [IF=27.338]

  7. Rowan MJ; Anwyl R; Lin Xu (1998) Stress and long-term synaptic depression. Molecular Psychiatry, 2: 472-476. [IF=6.250]

  8. Lin Xu; Holscher C; Anwyl R; Rowan MJ (1998) Glucorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress. Proc. Natl. Acad. Sci. USA, 95: 3204-3208. [IF=9.88]

  9. Lin Xu; Anwyl R; Rowan MJ (1997) Behavioural stress facilitate the induction of long-term depression in the hippocampus. Nature, 387: 497-500. [IF=27.338]

  10. Lin Xu; Anwyl R; Rowan MJ (1997) Role of 5-HT1a receptors and relationship to anxilytic effect. European Journal of Pharmacology, 323: 59-68. [IF=2.16]

  联系信息:

  Email:lxu@vip.163.com

  地址:昆明市教场东路32号中国科学院昆明动物研究所

  邮编:650223

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