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中科院动物研究所导师介绍:王雁玲


  姓名:王雁玲
  学科:发育生物学
  电话/传真:+86-10-64807195 /
  电子邮件:wangyl@ioz.ac.cn
  通讯地址:北京市朝阳区北辰西路1号院5号
  中国科学院动物研究所 计划生育生殖生物学国家重点实验室 100101
  更多信息:生殖病理学研究组 个人页面 English

  简历:
  王雁玲,女,1971年3月出生于青海省西宁市,博士,研究员,博士生导师;中国科学院动物研究生殖病理研究组组长。
  国家杰出青年基金获得者。1998年毕业于中国科学院动物研究所,获得生理学博士学位;2004年晋升为研究员。
  主要致力于研究胎盘发育的调控机理以及子痫前期等重大妊娠疾病的发病机制。我们建立和稳定了研究人类母胎界面上滋养层细胞和子宫内膜相互作用的多种体外模型,并通过慢病毒和腺病毒感染手段建立胎盘特异基因操作的动物模型;通过前瞻性分析建立子痫前期血浆和胎盘标本库;筛选和鉴定到子痫前期早期预测的血浆标记分子。正在应用业已建立的体内、外研究模型探讨标志分子相关的信号通路在早期胎盘发育中的作用,并研究其中关键因素的遗传和表观遗传调控异常与子痫前期发病的分子关联。我们的研究目标在于阐释人类胎盘发育的关键调控环节,揭示子痫前期发病的遗传和表观遗传基础,发展子痫前期早期诊断和干预的综合策略。
  近年来在Molecular Aspects of Medicine,Journal of Clinical Endocrinology and Metabolism,RNA Biology,PLoS ONE,Molecular Endocrinology,Human Reproduction,Biology of Reproduction等SCI期刊发表学术论文30余篇。

  社会任职:
  •2012- CoLab for Pregnancy国际组织中方代表
  •2012- “PLoS ONE”期刊编委
  •2011- “Frontiers in Experimental Endocrinology”杂志编委
  •2009- 中国动物学学会生殖生物学分会,理事
  •2008- 《医学分子生物学杂志》、《生殖医学杂志》等期刊编委
  •2007- 国家自然科学基金委员会,项目二审专家
  •2004- 美国生殖生物学学会(SSR),会员
  •2004- Molecular Human Reproduction,PLoS ONE,Journal of Cellular Physiology,BBRC,Journal of Molecular Histology,Endocrine,Journal of Obstetrics and Gynecology Research,Acta Genetics等国际期刊审稿人
  •2002- 中国细胞生物学学会,会员

  获奖及荣誉:
  •2008年,国家发明专利“一株人类胚胎滋养层细胞系的建立及其应用”(专利号ZL200510086506.X)
  •2007年,国家科学技术进步二等奖“子宫内膜异位症的基础与临床研究”(排名第五)
  •2006年,全国人口和计划生育科技工作先进个人
  •2005年,北京市科学技术奖一等奖“子宫内膜异位症的基础与临床研究”(排名第五)

  承担科研项目情况:
  1.正在执行的项目
  •国家杰出青年基金(81025004)胎盘发育与子痫前期发病机制(2011.01-2014.12),200万元
  •国家重大科学研究计划(2011CB944404):妊娠建立和维持的分子机制研究(2011.01-2014.12),主要研究骨干,200万元
  •中国科学院知识创新工程重要方向性项目(KSCX2-EW-R-06):重要妊娠相关疾病的分子标记和诊治策略研究(2011.01-2013.12),项目负责人,600万元
  2.已经完成的项目
  •NSFC-CIHR合作研究项目(30811120430)microRNA在先兆子痫发生中的作用(2009.01-2011.12),项目负责人,45万元
  •国家重点基础研究专项(973)课题(2006CB701502)非人灵长类克隆及治疗性克隆的机理研究-非人灵长类克隆胚重编程过程早期表达重要基因的克隆及功能研究(2006.01-2010.08),课题负责人,110万元
  •国家重大科学研究计划:生殖细胞健康与母胎识别及免疫豁免的分子基础(2006.01-2010.10),主要研究骨干,300万元
  •国家自然科学基金项目(No.30670786)基质金属蛋白酶-26在人滋养层细胞分化中的功能研究(2007.01-2009.12),项目负责人,35万元
  •国家自然科学基金重点项目(No.30530760)先兆子痫发病机理的研究(2006.01-2010.01),项目负责人,150万元
  •中国科学院知识创新工程重要方向性项目(No.KSCX2-YW-R-53)滋养层细胞分化相关分子的网络调控及其在先兆子痫发生中的作用(2006.09-2010.01),项目负责人,100万元
  •国家自然科学基金面上项目(No.30370542) 不同植入类型灵长类母胎界面上相关分子的表达及调控的分子机理(2004.01-2006.12),项目负责人,28万元
  •中科院知识创新重要方向项目子课题 (No.KSCX-2-SW-201) 生殖系统的功能基因组研究-胚胎植入关键基因筛选(2001.12- 2004.12),子课题负责人,81万元
  •国家自然科学基金面上项目(No.30070373) 端粒酶诱导人胚胎滋养层细胞永生化及其作用的分子机理(2001.01- 2003.12),项目负责人,25万元
  •国家重点基础研究发展专项子课题(No.G1999055903):人类生殖健康的基础研究-恒河猴胚胎植入关键基因的筛选和克隆(2000.09-2005.09),子课题负责人,85万元
  •国家自然科学基金重点项目(No.39830350):子宫内膜异位症发病机理的研究.(2000.01-2004.01),项目参加人,50万元

  代表论著:
  1.Ji L,Brkić J,Liu M,Fu G,Peng C*,Wang YL*.Placental trophoblast cell differentiation:physiological regulation and pathological relevance to preeclampsia.Mol Asp Med,2012 [Epub ahead of print]
  2.Fu G,Ye G,Nadeem L,Ji L,Manchanda T,Wang Y,Zhao Y,Qiao J,Wang YL,Lye S,Yang B B,and Peng C*.MicroRNA-376c Impairs Transforming Growth Factor-beta and Nodal Signaling to Promote Trophoblast Cell Proliferation and Invasion.Hypertension,2013 [Epub ahead of print]
  3.Yu L,Li D,Liao Q,Yang H,Cao B,Fu G,Ye G,Bai Y,Wang H,Cui N,Liu M,Li YX,Peng C,Wang YL*.High levels of ActivinA detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting Nodal signaling.J Clin Endo Metab,2012,97:E1370–E1379
  4.Yang Y,Wang Y,Zeng X,Ma XJ,Zhao Y,Qiao J,Cao B,Li YX,Ji L,Wang YL*.Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17.J Clin Endo Metab,2012,97:E1390–E1401
  5.Bai Y,Yang W,Yang H,Liao Q,Ye G,Fu G,Ji L,Xu P,Wang H,Li YX,Peng C,Wang YL*.Downregulated miR-195 detected in preeclamptic placenta affects trophoblast cell invasion via modulating ActRIIA expression.PLoS ONE,2012,2012;7(6):e38875
  6.Gao WL,Liu M,Li D,Yang H,Liao Q,Yang Y,Bai Y,Li YX,Peng C,Wang YL*.The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1).RNA Biol,2012,9:1002-1010
  7.Gao WL,Li D,Xiao Z,Liao QP,Yang HX,Li Y,Ji L and Wang YL*.Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas.Hyp Res,2011 34(5):655-61
  8.Liu J,Cao B,Li YX,Wu XQ,Wang YL*.GnRH I and II up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts.Reprod Biol Endocrinol,2010,8:5-
  9.Fu YY,Gao WL,Chen MQ,Chai KX,Wang YL*,Chen LM.Prostasin Regulates Human Placental Trophoblast Cell Proliferation via the EGFR Signaling Pathway.Hum Reprod,2010,5:623-632
  10.Wang YL*,Cheng LZ.Regulation of primate trophoblast lineage differentiation – Insights learned from human embryonic stem cells.Reprod Biol Insights,2009,2:11-21
  11.Liu J,MacCalman CD,Wang YL*,Leung PC*.Promotion of Human Trophoblasts Invasion by Gonadotropin-Releasing Hormone (GnRH) I and GnRH II via Distinct Signaling Pathways.Mol Endocrinol,2009,23(7):1014-1021
  12.Zhao MR,Qiu W,Li YX,Sang QX,Wang YL*.Dynamic change of adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells.Sci China Ser C – Life Sci,2009,52:710-718
  13.Zeng X,Sun Y,Yang H,Li D,Li YX,Liao QP *,Wang YL *.Plasma level of soluble Met is tightly associated with the clinical risk of preeclampsia.Am J Ob Gyn,2009,201(6):618-619
  14.Ma XJ,Fu YY,Li YX,Chen LM,Chai K,Wang YL*.Prostasin Inhibits Cell Invasion in Human Choriocarcinomal JEG-3 Cells.Histochem Cell Biol,2009,132(6),pp 639-646
  15.Wang YL*,Wu X,Liu J,Li Y,Cao B,Leung PCK.Effect of matrix metalloproteinase-26 on cell invasion and its modulation by gonadotropin releasing hormones in human trophoblast cells.In Translational research in Uterine Biology.Editors,MaruoT,MardonH,and Stewart C.2008,Elsevier.pp137-147
  16.Liu J,Li D,Cao B,Li YX,Herva R,Piao YS and Wang YL*.Expression and localization of SWAP-70 on human feto-maternal interface during fallopian implantation and normal pregnancy.J Histochem Cytochem,2007,55(7):701-708
  17.Mardon HJ,Bagchi MK,Bagchi IC,Peng C,Karpovich N and Wang Y.Hormonal and paracrine Regulation of embryonic implantation:A workshop report.Placenta,2007,28 Suppl A:S82-84
  18.Zhao MR,Qiu W,Li YX,Zhang ZB,Li D,Wang YL*.Dual effect of TGFb1 on cell adhesion and invasion in human normal placenta trophoblast cells.Reproduction,2006,132:333-341
  19.Wang YL*,Qiu W,Feng HC,Zhuang LZ,Wang Z,Liu Y,Zhou JQ,Zhang DH,Tsao SW*.An immortalized normal human cytotrophoblast cell line generated by exogenous expression of telomeric reverse transcriptase.Mol Hum Reprod,2006,12:451-460
  20.Liu J,Fu YY,Sun XY,Li FX,Li YX,Wang YL*.Expression of SWAP-70 in the uterus and feto-maternal interface during embryonic implantation and pregnancy in the rhesus monkey (Macaca mulatta).Histochem Cell Biol.2006,126(6):695-704
  21.Tan YF,Sun X,Li F,Tang S,Piao YS,Wang YL*.Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy.Reprod Nutr Dev,2006,46:641–655
  22.Qiu W,Bai SX,Zhao MR,Wu XQ,Zhao YG,Sang QX,Wang YL* Spatio-temporal expression of matrix metalloproteinase-26 in human placental trophoblasts and fetal red cells during normal placentation.Biol Reprod,2005,72:954–959
  23.Bai SX,Wang YL*,Qin L,Xiao ZJ,Herva R and Piao YS*.Dynamic expression of matrix metalloproteinases (MMP-2,-9 and -14) and the tissue inhibitors of MMPs (TIMP-1,-2 and -3) at the implantation site during tubal pregnancy.Reproduction,2005,129:103-113
  24.Cheng GJ,Li Y,Omoto Y,Wang YL,Berg T,Nord M,Vihko P,Warner M,Piao YS and Gustafsson J*.Differential regulation of ERa and ERb in primate mammary gland.J Clin Endocrinol Metab,2005,90(1):435-444
  25.Sun XY,Li FX,Li J,Tan YF,Piao YS,Tang S,Wang YL*.Determination of genes involved in the early process of embryonic implantation in rhesus monkey (Macaca mulatta) by suppression subtractive hybridization.Biol Reprod,2004,70:1365-1373
  26.Feng H,Cheung ANY,Xue WC,Wang YL,Wang X,Fu S,Wang Q,Ngan HYS,Tsao SW*.Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma.Gynecol Oncol,2004,94:375-382.
  27.Qin L,Wang YL*,Bai S,Ji S,Qiu W,Tang S,Piao YS.Temporal and spatial expression of integrins and their extracellular matrix ligands at the maternal-fetal interface in the rhesus monkey during pregnancy.Biol Reprod,2003,69:563-571
  28.Tan YF,Sun XY,Li FX,Piao YS,Wang YL*.Global gene profiling of mouse uterine endometrium during normal estrol cycle.Reproduction,2003,126:171-182
  29.Qin L,Wang YL*,Bai SX,Xiao ZJ,Herva R,Piao YS.Expression of integrins and extracellular matrix proteins at the maternal-fetal interface during tubal implantation.Reproduction,2003,126:383-391
  30.Xu P,Wang YL,Bai S,Xiao ZJ,Jia Y,Luo S,Piao YS,Zhuang LZ*.Effect of matrix proteins on the expression of matrix metalloproteinase-2,-9,-14 and tissue inhibitors of metalloproteinases in human cytotrophoblast cells during the first trimester.Biol Reprod,2001,65:240-246
  31.Wang YL,Liu Y,Piao YS,Zhuang LZ,Tsao SW*.Immortalization of normal human placenta-origin cytotrophoblast cell line (NPC) by regeneration of telomerase activity.Biol Reprod,2000,62 (suppl.):312-313
  32.Xu P,Wang YL,Zhu SJ,Luo S,Piao YS,Zhuang LZ*.Expression of matrix metalloproteinase-2,-9,-14,tissue inhibitors of metalloproteinase-1,and matrix proteins in human placenta during the first trimester.Biology of Reproduction,2000,62:988-994
  33.Wang YL,Mather JP,Woodroff T,Luo S,Zhuang LZ*.Regulation of activin A in cell proliferation and hormone secretion by human normal trophoblast cells.Chin Sci Bul,1999,44:609-612

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