中科院动物研究所导师介绍:王海滨
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姓名:王海滨 学科:发育生物学 电话/传真:+86-10-64807868 / 电子邮件:hbwang@ioz.ac.cn
姓名:王海滨
学科:发育生物学
电话/传真:+86-10-64807868 /
电子邮件:hbwang@ioz.ac.cn
通讯地址:北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 计划生育生殖生物学国家重点实验室 100101
更多信息:胚胎着床生理学研究组 个人页面 English
简历:
王海滨,男,1974年9月出生于浙江省义乌市,博士,研究员,博士生导师;中国科学院动物研究所胚胎着床生理学研究组组长。
“百人计划”引进海外杰出人才,国家杰出青年基金获得者,国家重大研究计划首席科学家。2000-2001年作为短期交换留学生在日本东京农工大农学部田谷一善先生研究室从事合作研究。2001年毕业于中国农业大学,获生理学理学博士学位。2001-2004年在美国堪萨斯大学医学中心和范德堡大学医学中心SK Dey 先生研究室进行博士后培训,曾获 Lalor Foundation 博士后基金资助。2004-2007年在范德堡大学医学中心儿科系先后担任研究助理教授和助理教授。目前主要从事早期胚胎发育、着床和胎盘发生的分子机制研究,相关研究工作以第一作者或通讯作者分别发表在Nat Med、J Clin Invest、PLoS Biology、PNAS、Development、JBC等杂志上,已发表SCI论文50多篇,SCI论文他引率2000多次,并于2006年、2010年、2012年分别受邀为Nat Rev Genet、Endocrine Rev、 J Clin Invest、Mol Aspect Med等杂志撰写特邀综述。王海滨博士多次受邀参加生殖生物学Keystone Symposia并做大会报告,目前担任Biol Reprod、PLoS ONE等杂志编委会委员。
社会任职:
•美国生殖生物学学会(Society for the Study of Reproduction)会员(2001-)
•美国内分泌学会(Endocrine Society)会员(2004-)
•美国生殖免疫学会(American Society of Reproductive Immunology)会员(2010-)
•Am J ReprodImmunol杂志编委会委员(2010-)
•PLoS ONE杂志编委会委员(2010-)
•Reprod Med Biol杂志编委会委员(2011-)
•Development & Reproduction杂志编委会委员(2011-)
•Biol Reprod杂志编委会委员(2012-)
•Invited Guess Editor,Molecular Aspects of Medicine. 2013年特刊:Regulation of Early Pregnancy
•Invited Guess Editor,International Journal of Endocrinology. 2013年特刊:Endocannabinoids and Reproduction
此外,是领域内许多国际刊物,如Nat Med、JCI、JAMA、JBC、Mol Endocrinol、Endocrinology、Biol Reprod、Reproduction、Hum Reprod、Mol Hum Reprod、Fertil Steril、PLoS ONE、BMC Genomics、Placenta等的ad hoc审稿
获奖及荣誉:
•Lalor博士后基金
•Solvay/Joseph Mortola研究奖,由美国妇科研究学会(the Society for Gynecologic Investigation,SGI)颁发,2005年度唯一获奖人
•“百人计划”引进国外人才(2008-2012年)
•国家杰出青年基金获得者(2008年)
•973首席科学家(2011年)
•中国科学院青年科学家奖(2011年)
承担科研项目情况:
•基金委重点项目-母-胎互作微环境决定妊娠结局的分子基础(81130009),2012-2016
•青年科学基金项目-组蛋白H2A 泛素E3 连接酶Bmi1 和Mel18 在胚胎着床中的作用(31200881),2012-2015
•国家杰出青年基金项目-胚胎发育与着床/Wnt信号通路在胚泡着床和子宫蜕膜反应中的生理作用(30825015),2009-2012
•国家重大科学研究计划(973)项目-妊娠建立和维持的分子机制研究(2011CB944400)2011-2015
•国家重大基础研究(973)项目“卵巢衰老及相关重大疾病的基础研究”二级课题-卵巢衰老诱发女性生殖系统疾病的分子机理(2010CB945002),2010-2015
国际学术会议主席和特邀大会报告:
•Invited speaker,Keystone Symposia (Reproduction:Advances and Challenges),Santa Fe,New Mexico,USA,February 20-25,2007
•Invited speaker,Keystone Symposia (Reproduction:Frontiers in Reproductive Biology and Regulation of Fertility),Santa Fe,New Mexico,USA,February 1-6,2009
•Co-chair (Enkui Duan,Haibin Wang,Sudhansu K. Dey and Bruce Murphy),SKLRB Symposia on Frontiers in Periimplantation Biology,Beijing,China May 8-12,2010
•Nature Conference:The Herrenhausen Symposium on Reproductive Biology,Germany,,October 4-7,2011
•Plenary speaker,the 2nd World Congress on Reproductive Biology (WCRB),Cairns,Queensland,Australia,October 9-12,2011
•Co-chair (Enkui Duan,Haibin Wang,Susan J. Fisher and Sudhansu K. Dey),SKLRB Symposia on Frontiers in Reproductive Biology,Beijing,China,May 6-11,2012
代表论著:
1.Lu J,Zhang S,Nakano N,Simmons DG,Wang S,Wang Q,Kong S,Shen L,Wang W,Wang B,Wang HM,Wang YL,van Es JH,Clevers H,Leone G,Cross JC,Wang H*. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biology.2013.11(4)
2.Zhang S,Lin H,Kong S,Wang S,Wang H,Wang H*,Armant DR* (Co-correspondence)..Physiological and molecular determinants of embryo implantation. Mol Aspects Med. 2013 Jan 2. doi:pii:S0098-2997(12)00158-6. 10.1016/j.mam.2012.12.011. [Epub ahead of print]
3.Wang Q,Lu J,Zhang S,Wang S,Wang W,Wang B,Wang F,Chen Q,Duan E,Leitges M,Kispert A,Wang H*. Wnt6 is essential for stromal cell proliferation during decidualization in mice. Biol Reprod. 88(1):5,2013
4.Zhang S,Kong S,Lu J,Wang Q,Chen Y,Wang W,Wang B,Wang H*. Deciphering the molecular basis of uterine receptivity. Mol Reprod Dev. 80(1):8-21,2013
5.Kong S,Zhang S,Chen Y,Wang W,Wang B,Chen Q,Duan E*,Wang H*. Determinants of uterine aging:lessons from rodent models. Sci China Life Sci. 55(8):687-93,2012
6.Lim H & Wang H* (Co-correspondence). Uterine disorders and pregnancy complications:insights from mouse models. J CIin Invest. 120(4),1004-15,2010
7.Chen Q,Zhang Y,Lu J,Wang Q,Wang S,Cao Y,Wang H*,Duan E* (Co-correspondence). Embryo-uterine cross-talk during implantation:The role of Wnt signaling. Mol Hum Reprod. 15(4):215-21,2009
8.Xie H,Tranguch S,Jia X,Zhang H,Das SK,Dey SK,Kuo CJ,and Wang H* (*Correspondence). Inactivation of Nuclear Wnt-β-Catenin Signaling Limits Blastocyst Competency for Implantation. Development. 135(4):717-727,2008
9.Wang H*,Xie H*(equal contribution),Dey SK. Loss of cannabinoid receptor CB1 induces preterm birth. PLoS ONE. 3(10):e3320,2008
10.Xie H*,Wang H* (equal contribution),Tranguch S,Iwamoto R,Mekada E,DeMayo FJ,Lydon JP,Das SK and Dey SK. Heparin-binding EGF-like growth factor serves as a molecular link between the blastocyst and uterus during implantation. PNAS. 104(46):18315-20,2007
11.Wang H*,Xie H* (equal contribution),Sun X,Tranguch S,Zhang H,Jia X,Wang D,Das SK,Desvergne B,Wahli W,DuBois RN and Dey SK. Stage-specific integration of maternal and embryonic PPARδ signaling is critical to pregnancy success. J Biol Chem. 282(52):37770-37782,2007
12.Wang H*,Xie H*,Sun X* (equal contribution),Kingsley PJ,Marnett LJ,Cravatt BF and Dey SK. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins Other Lipid Mediat.83(1-2):62-74,2007
13.Wang H*,Xie H,Guo Y,Zhang H,Takahashi T,Kingsley PJ,Marnett LJ,Das SK,Cravatt BF and Dey SK. Fatty acid amide hydrolase deficiency limits early pregnancy events. J CIin Invest. 116 (8):2122-2131,2006
14.Wang H*,Dey SK and Maccarrone M. Jekyll and Hyde:Two faces of cannabinoid signaling in male and female fertility. Endocr Rev. 27 (5):427-448,2006
15.Wang H* and Dey SK. Roadmap to embryo implantation:Clues from mouse models. Nat Rev Genet. 7 (3):185-199,2006
16.Wang H*,Xie H and Dey SK. Endocannabinoid signaling directs periimplantation events. AAPS J. 8 (2):E425-E432,2006
17.Wang H*,Xie H* (equal contribution),Zhang H,Das SK and Dey SK. Conditional gene recombination by adenovirus-driven Cre in the mouse uterus. Genesis. 44(2):51-56,2006
18.Lei L,Zhang H,Jin S,Wang F,Fu M,Wang H* and Xia G* (co-correspondence). Stage-specific germ-somatic cell interaction directs the primordial folliculogenesis in mouse fetal ovaries. J Cell Physiol. 208(3):640-647,2006
19.Wang H*,Tranguch S* (equal author),Xie H,Hanley G,Das SK,Dey SK. Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus. PNAS. 102 (28):9960-9965,2005
20.Wang H* and Dey SK. Lipid Signaling in Embryo Implantation. Prostaglandins Other Lipid Mediat. 77(1-4):84-102,2005
21.Guo Y*,Wang H* (equal author),Okamoto Y,Ueda N,Kingsley PJ,Marnett LJ,Schmid HH,Das SK,Dey SK. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J Biol Chem. 280 (25):23429-23432,2004
22.Wang H*,Ma W,Tejada L,Zhang H,Morrow JD,Das SK,and Dey SK. Rescue of female infertility from the loss of Cyclooxygenase-2 by compensatory upregulation of Cyclooxygenase-1 is a function of genetic make-up. J Biol Chem. 279(11):10649-10658,2004
23.Wang H*,Guo Y,Wang D,Kingsley PJ,Marnett LJ,Das SK,DuBois RN and Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med.10(10):1074-1080,2004
24.Wang H*,Matsumoto H,Guo Y,Paria BC,Roberts RL,and Dey SK. Differential G-Protein coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. PNAS. 100(25):14914-14919,2003
25.Wang H*,Herath CB,Xia GL,Watanabe G,and Taya K. Superovulation,fertilization and in vitro embryo development in the mouse after administration of inhibin-neutralizing antiserum. Reproduction. 122(5):809-816,2001
写给考生的话:
“A career in science is a journey of wonder and discovery. To succeed in science requires curiosity,perseverance,a good dose of luck,and wise guidance from those who have taken the journey ahead of you”—— Janet Rossant
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