中科院动物研究所导师介绍:邱星辉
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姓名:邱星辉 学科:生物化学与分子生物学 电话/传真:+86-10-64807231 / +86-10-64807099
姓名:邱星辉
学科:生物化学与分子生物学
电话/传真:+86-10-64807231 / +86-10-64807099
电子邮件:qiuxh@ioz.ac.cn
通讯地址:北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 农业虫害鼠害综合治理研究国家重点实验室 100101
更多信息:昆虫毒理学与生物技术研究组 个人页面 English
简历:
邱星辉,男,理学博士,研究员,昆虫毒理学与生物技术研究组组长。
分别于1991年、1998年在中国科学院获生态学硕士和动物学 (昆虫毒理学方向)博士学位。现为农业虫害鼠害综合治理研究国家重点实验室研究员,昆虫毒理学与生物技术研究组组长,兼任卫生部病媒生物控制专业委员会委员、北京市爱卫会专家委员会委员、中国昆虫学会常务理事。2001年2月-2002年5月澳大利亚联邦科学与工业研究组织(CSIRO)生物技术项目访问学者,2007年1月-2008年1月美国Purdue University基因组学实验室访问学者。至今在国内外发表论文80篇(其中SCI论文25篇),专著1部,授权国家发明专利1项。曾于1997年获中国科学院自然科学奖一等奖,1999年获国家自然科学奖三等奖。
研究领域:
该实验室的目标是运用基因组学、生物化学、毒理学和分子生物学技术,解决重要农业、环境与食品安全领域的基础科学问题和实际问题。近年来的研究工作主要集中在以下几个方面:(1)细胞色素P450酶系的功能与调控;(2)有毒物质的生物转化,重点在外源有害物质的生物降解途径分析和降解酶基因的分离、表达与调控研究;(3)昆虫毒理基因组学,在基因组尺度上研究杀虫剂毒性和昆虫抗药性的分子机制。
承担科研项目情况:
研究工作得到国家重点基础研究计划(973)、国家自然科学基金面上项目和中国科学院创新方向项目的资助。
代表论著:
1.Yang J,An J,Li M,Hou X,Qiu X* 2013 Characterization of chicken cytochrome P450 1A4 and 1A5:Inter-paralog comparisons of substrate preference and inhibitor selectivity.Comparative Biochemistry and Physiology,Part C 157 (2013) 337–343.
2.Qiu X,Sun W,McDonnell C,Li H,Steele LD,Wu J,Xie J,Muir W,and Pittendrigh.BR.2013.Genome-wide analysis of genes associated with moderate and high DDT resistance in Drosophila melanogaster.Pest Management Science.DOI:10.1002/ps.3454
3.Frank D.Rinkevich,Shannon M.Hedtke,Cheryl A.Leichter,Sarah A.Harris,Cathy Su,Seán G.Brady,Vatan Taskin,Xinghui Qiu & Jeffrey G.Scott.2012.Multiple Origins of kdr-type Resistance in the House Fly,Musca domestica.Plosone 7(12):e52761.doi:10.1371/ journal.pone.0052761
4.Gao Q,Li M,Sheng C,Scott JG,Qiu X*,2012.Multiple cytochrome P450s overexpressed in pyrethroid resistant house flies (Musca domestica).Pesticide Biochemistry and Physiology 104:252-260
5.Qiu X*,Pan J,Li M,Li Y,2012.PCR-RFLP methods for detection of insecticide resistance-associated mutations in the house fly (Musca domestica).Pesticide Biochemistry and Physiology 104 :201–205
6.Wang Q,Li M,Pan J,Di M,Liu Q,Meng F,Scott JG,Qiu X*,2012 Diversity and frequencies of genetic mutations involved in insecticide resistance in field populations of the house fly (Musca domestica L.) from China.Pesticide Biochemistry and Physiology,102:153-159
7.Zhou X,Li M ,Sheng C,Qiu X*,2011,NADPH-cytochrome P450 oxidoreductase from the chicken (Gallus gallus):sequence characterization,functional expression and kinetic study.Comparative Biochemistry and Physiology,Part C,153:53-59.8.Wang D,Qiu X,Wang H,Qiao K,Wang K,2010.Reduced fitness associated with spinosad resistance in Helicoverpa armigera.Phytoparasitica 38:103–110 9.Zhou X,Sheng C,Li M,Wan H,Liu D,Qiu X*,2010.Expression responses of nine cytochrome P450 genes to xenobiotics in the cotton bollworm Helicoverpa armigera,Pesticide Biochemistry and Physiology 97:209-213
10.Zhou X.,Ma C,Sheng C,Liu H,Gong P,Qiu X*,2010,CYP9A12 and CYP9A17 in the cotton bollworm,Helicoverpa armigera:sequence similarity,expression profile and xenobiotic response.Pest Management Science,66:65-73.
11.Qiu X *,Wu P,Zhang H,Li M,Yan Z,2009.Isolation and characterization of Arthrobacter sp.HY2 capable of degrading a high concentration of p-nitrophenol.Bioresource Technology,100:5243-5248
12.Wang D,Qiu X*,Ren X,Zhang W,Wang K*,2009,Effects of spinosad on Helicoverpa armigera (Lepidoptera:Noctuidae) from China:tolerance status,synergism and enzymatic responses.Pest Management Science,65:1040-1046
13.Wang D.Qiu X.Ren X,Niu F,Wang K*,2009,Resistance selection and biochemical characterization of spinosad resistance in Helicoverpa armigera (Hubner)(Lepidoptera:Noctuidae) Pesticide Biochemistry and Physiology,95:90-94.
14.Wang D,Gong P,Li M,Qiu X*,Wang K*,2009,Sublethal effects of spinosad on survival,growth and reproduction of Helicoverpa armigera (Lepidoptera:Noctuidae).Pest Management Science,65(2):223-227
15.Xu J.Yang M .Dai J.Cao H.Pan C.Qiu X*.Xu M.2008,Degradation of acetochlor by four microbial communities.Bioresource Technology 99:7797–7802
16.Qiu X*,Li M,Luo H,Fu T.,2007,Molecular analysis of resistance in a deltamethrin-resistant strain of Musca domestica from China.Pesticide Biochemistry and Physiology,89(2):146-150
17.Zhong Q,Zhang H,Bai W,Li M,Li B,Qiu X*,2007.Degradation of aromatic compounds and degradation pathway of 4-nitrocatechol by Ochrobactrum sp.B2.Journal of Environmental Science and Health,Part A 42:2111-2116
18.Qiu X*,Zhong Q,Li M,Bai W,Li B,2007.Biodegradation of p-nitrophenol by methyl parathion-degrading Ochrobactrum sp.B2.International Biodeterioration & Biodegradation 59 (4) :297-301
19.Qiu X*,Bai W,Zhong Q,Li M,He F,Li B,2006.Isolation and characterization of a bacterial strain of the genus Ochrobactrum with methyl parathion mineralizing activity.Journal of Applied Microbiology.101:986-994.
20.Horne I,Qiu X,Ollis DL,Russell RJ,Oakeshott JG,2006.Functional effects of amino acid substitutions within the large binding pocket of the phosphotriesterase OpdA from Agrobacterium sp.P230.FEMS Microbiol.Lett.,259:187-194.
21.Xu J,Qiu X,Dai J,Cao H,Yang M,Zhang J,Xu M.,2006,Isolation and characterization of a Pseudomonas oleovorans degrading the choloracetamide herbicide acetochlor.Biodegradation,17:219-225
22.Horne I,Qiu X,Russell RJ,Oakeshott JG.2003 The phosphotriesterase gene opdA in Agrobacterium radiobacter P230 is transposable.FEMS Microbiol Lett,222(1):1-8
23.Yang H,Carr PD,McLoughlin SY,Liu JW,Horne I,Qiu X,Jeffries CM,Russell RJ,Oakeshott JG,Ollis DL,2003.Evolution of an organophosphate-degrading enzyme:a comparison of natural and directed evolution.Protein Eng.,16(2):135-45
24.Qiu X,Li W,Tian Y,Leng X,2003.Cytochrome P450 monooxygenase in the cotton bollworn(Lepidoptera:Noctuidae):tissue difference and induction.J Econ.Entomol.96(4):1283-1289
25.Qiu X,Li W,Leng X,2001 Cytochrome P450 monooxygenases in the cotton bollworm,Helicoverpa armigera (Lepidoptera:Noctuidae):in vivo effects of deltamethrin exposure.J Agric.Urban Entomol.18(4):217-225
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