中科院动物研究所导师介绍:孟安明
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姓名:孟安明 学科:细胞生物学 电话/传真:+86-10-64807213 / +86-10-64807099 电子邮件:mengam
姓名:孟安明
学科:细胞生物学
电话/传真:+86-10-64807213 / +86-10-64807099
电子邮件:mengam@ioz.ac.cn
通讯地址:北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 生物膜与膜生物工程国家重点实验室 100101
更多信息:胚胎发育信号转导研究组 个人信息 English
简历:
2000年获得国家杰出青年基金、香港求是基金会“杰出青年学者奖”、教育部跨世纪人才基金、教育部优秀青年教师奖,2001年入选第四批教育部长江学者计划特聘教授,2007年获得何梁何利基金科学与技术进步奖。
1979.9 -1983.7,西南农业大学农学系本科生;
1983.8 -1987.5,中国水稻研究所实习研究员;
1987.5 -1990.11,英国诺丁汉大学遗传系博士生;
1990.12 -1998.8,先后在北京农业大学(现中国农业大学)做博士后研究和任副教授;
1996.3-1998.8,在美国佐治亚医学院做访问研究;
1998.9以来,清华大学生物系教授;
2008.3-中国科学院动物研究所研究员。
研究领域:
主要利用斑马鱼为模式动物,结合分子生物学、细胞生物学、遗传学等技术,研究TGF-β/Nodal等重要信号通路在胚胎发育中的作用及分子机制,以及microRNA在斑马鱼早期胚胎发育中的功能。
社会任职:
现任中国动物学会副理事长,Current Zoology主编、BMC Developmental Biology副主编、JCS和JBC编委会成员。
获奖及荣誉:
2000年获得国家杰出青年基金、香港求是基金会“杰出青年学者奖”、教育部跨世纪人才基金、教育部优秀青年教师奖,2001年入选第四批教育部长江学者计划特聘教授,2007年获得何梁何利基金科学与技术进步奖。
代表论著:
1.Liu,X.,Ning,G.,Meng,A.M.,and Wang,Q.(2012).MicroRNA-206 Regulates Cell Movements during Zebrafish Gastrulation by Targeting prickle1a and Regulating c-Jun N-Terminal Kinase 2 Phosphorylation.Mol Cell Biol 32,2934-2942.
2.Jia,S.,Dai,F.,Wu,D.,Lin,X.,Xing,C.,Xue,Y.,Wang,Y.,Xiao,M.,Wu,W.,Feng,X.H.,and Meng,A.M.(2012).Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos.Dev Cell 22,1065-1078.
3.Wang,Y.,Li,Z.,Xu,P.,Huang,L.,Tong,J.,Huang,H.,and Meng,A.M.(2011).Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis.J Biol Chem 286,41095-41104.
4.Liu,Z.,Lin,X.,Cai,Z.,Zhang,Z.,Han,C.,Jia,S.,Meng,A.M.,and Wang,Q.(2011).Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas.J Biol Chem 286,28520-28532.
5.Han,Y.,Mu,Y.,Li,X.,Xu,P.,Tong,J.,Liu,Z.,Ma,T.,Zeng,G.,Yang,S.,Du,J.,and Meng,A.M.(2011).Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28.Hum Mol Genet 20,3213-3226.
6.Zhao,X.,Zhao,L.,Tian,T.,Zhang,Y.,Tong,J.,Zheng,X.,and Meng,A.M.(2010).Interruption of cenph causes mitotic failure and embryonic death,and its haploinsufficiency suppresses cancer in zebrafish.J Biol Chem 285,27924-27934.
7.Zhang,Y.,Li,X.,Qi,J.,Wang,J.,Liu,X.,Zhang,H.,Lin,S.C.,and Meng,A.M.(2009).Rock2 controls TGFbeta signaling and inhibits mesoderm induction in zebrafish embryos.J Cell Sci 122,2197-2207.
8.Li,X.,Jia,S.,Wang,S.,Wang,Y.,and Meng,A.M.(2009).Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos.Blood 114,5464-5472.
9.Jia,S.,Wu,D.,Xing,C.,and Meng,A.M.(2009).Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish.Dev Biol 333,273-284.
10.Zhao,L.,Zhao,X.,Tian,T.,Lu,Q.,Skrbo-Larssen,N.,Wu,D.,Kuang,Z.,Zheng,X.,Han,Y.,Yang,S.,Zhang,C.,and Meng,A.M.(2008).Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos.Cardiovasc Res 80,200-208.
11.Meng,F.,Cheng,X.,Yang,L.,Hou,N.,Yang,X.,and Meng,A.M.(2008).Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGFbeta signaling.J Cell Sci 121,2904-2912.
12.Jia,S.,Ren,Z.,Li,X.,Zheng,Y.,and Meng,A.M.(2008).smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafish.J Biol Chem 283,2418-2426.
13.Su,Y.,Zhang,L.,Gao,X.,Meng,F.,Wen,J.,Zhou,H.,Meng,A.M.,and Chen,Y.G.(2007).The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling.FASEB J 21,682-690.
14.Rui,Y.,Xu,Z.,Xiong,B.,Cao,Y.,Lin,S.,Zhang,M.,Chan,S.C.,Luo,W.,Han,Y.,Lu,Z.,Ye Z.,Zhou H.,Han J.,Meng A.M.,Lin S.(2007).A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.Dev Cell 13,268-282.
15.Huang,H.,Lu,F.I.,Jia,S.,Meng,S.,Cao,Y.,Wang,Y.,Ma,W.,Yin,K.,Wen,Z.,Peng,J.,Thisse C.,Thisse B.,Meng A.M.(2007).Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation.Development 134,979-988.
16.Xiong,B.,Rui,Y.,Zhang,M.,Shi,K.,Jia,S.,Tian,T.,Yin,K.,Huang,H.,Lin,S.,Zhao X.,Chen Y.,Chen Y.G.,Lin S.C.,Meng A.M.(2006).Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.Dev Cell 11,225-238.
17.Lin,X.,Duan,X.,Liang,Y.Y.,Su,Y.,Wrighton,K.H.,Long,J.,Hu,M.,Davis,C.M.,Wang,J.,Brunicardi,F.C.,Shi Y.G.,Chen Y.G.,Meng A.M.,Feng X.(2006).PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.Cell 125,915-928.
18.Zhang,L.,Zhou,H.,Su,Y.,Sun,Z.,Zhang,H.,Zhang,Y.,Ning,Y.,Chen,Y.G.,and Meng,A.M.(2004).Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors.Science 306,114-117.
19.Penberthy,W.T.,Zhao,C.,Zhang,Y.,Jessen,J.R.,Yang,Z.,Bricaud,O.,Collazo,A.,Meng,A.M.,and Lin,S.(2004).Pur alpha and Sp8 as opposing regulators of neural gata2 expression.Dev Biol 275,225-234.
20.Cao,Y.,Zhao,J.,Sun,Z.,Zhao,Z.,Postlethwait,J.,and Meng,A.M.(2004).fgf17b,a novel member of Fgf family,helps patterning zebrafish embryos.Dev Biol 271,130-143.
21.Zhao,J.,Cao,Y.,Zhao,C.,Postlethwait,J.,and Meng,A.M.(2003).An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction.EMBO J 22,6078-6088.
22.Zhao,Z.,Cao,Y.,Li,M.,and Meng,A.M.(2001).Double-stranded RNA injection produces nonspecific defects in zebrafish.Dev Biol 229,215-223.
23.Zhang,L.,Hua,Z.,Ren,J.,and Meng,A.M.(2001).The nuclear localization signal of zebrafish terra is located within the DM domain.FEBS Lett 503,25-29.
24.Meng,A.M.,Tang,H.,Yuan,B.,Ong,B.A.,Long,Q.,and Lin,S.(1999).Positive and negative cis-acting elements are required for hematopoietic expression of zebrafish GATA-1.Blood 93,500-508.
25.Meng,A.M.,Moore,B.,Tang,H.,Yuan,B.,and Lin,S.(1999).A Drosophila doublesex-related gene,terra,is involved in somitogenesis in vertebrates.Development 126,1259-1268.
26.Meng,A.M.,Jessen,J.R.,and Lin,S.(1999).Transgenesis.Methods Cell Biol 60,133-148.
27.Jessen,J.R.,Meng,A.M.,McFarlane,R.J.,Paw,B.H.,Zon,L.I.,Smith,G.R.,and Lin,S.(1998).Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis.Proc Natl Acad Sci U S A 95,5121-5126.
28.Meng,A.M.,Tang,H.,Ong,B.A.,Farrell,M.J.,and Lin,S.(1997).Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2.Proc Natl Acad Sci U S A 94,6267-6272.
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