中科院动物研究所导师介绍:韩春生
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姓名:韩春生 学科:发育生物学 电话/传真:+86-10-64807105 / 电子邮件:hancs@ioz.ac.cn
姓名:韩春生
学科:发育生物学
电话/传真:+86-10-64807105 /
电子邮件:hancs@ioz.ac.cn
通讯地址:北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 计划生育生殖生物学国家重点实验室 100101
更多信息:生物信息学研究组 个人页面 English
简历:
韩春生,男,1968年3月出生于山西省晋中市,博士,研究员,博士生导师;中国科学院动物研究所生物信息学研究组组长。
中科院“百人计划”海外杰出人才入选者。1990年复旦大学遗传工程专业本科毕业,1993年获生殖生物学国家重点实验室生理学硕士,2000年获美国密苏里州立大学生物化学博士学位,2000年至2003年任美国Lexicon Genetics & Pharmaceuticals 公司高级生物信息科学家。美国生殖生物学学会会员。曾从事包括胚胎着床、干扰素信号传导、基因制药以及生物信息学等领域的研究,在"PNAS"、 "Endocrinology"、"Biology of Reproduction"、"Current Opinion in Biotechnology"等杂志上发表学术论文。目前的研究重点有两个:第一,面向不育治疗新技术及新型转基因技术的研发,建立精原干细胞的体外培养、转基因及移植技术,以精原干细胞为模型对干细胞的增殖与分化及精子发生机理进行研究;第二,面向新一代避孕药物的研发,利用生物信息学手段挖掘配子发生过程中的重要基因(蛋白质编码基因和小分子RNA),利用分子生物学、细胞生物学、转基因小鼠等技术对基因的功能进行深入研究。承担国家自然科学基金、科技部重大研究计划、“973”等项目的研究课题。
承担科研项目情况:
国家自然科学基金面上项目
国家重大研究计划项目
国家“973”计划课题
中国科学院重要方向项目
代表论著:
Gan,H.,Wen,L.,Liao,S.,Lin,X.,Ma,T.,Liu,J.,Song,C.-x.,Wang,M.,He,C.,Han,C.*,and Tang,F.(2013)Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis,Nature Communications (doi:10.1038/ncomms2995).
Wang,F.,Yang,Y.,Lin,X.,Wang,J.Q.,Wu,Y.S.,Xie,W.,Wang,D.,Zhu,S.,Liao,Y.Q.,Sun,Q.,Yang,Y.G.,Guo,C.*,Han,C.*,and Tang,T.S.* (2013)Genome-wide Loss of 5-hmC is a Novel Epigenetic Feature of Huntington's Disease,Human Molecular Genetics (doi:10.1093/hmg/ddt214).
Wu,Y.,Liao,S.,Wang,X.,Wang,S.,Wang,M.,and Han,C.* (2013)HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm,FEBS Letters (10.1016/j.febslet.2013.04.049).
Shi,Y.,Zhuang,X.,Xu,B.,Hua,J.,Liao,S.,Shi,Q.,Cooke,H.J.,Han,C.* (2013)SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60,Gene(10.1016/j.gene.2013.06.033)
Gan,H.,Cai,T.,Lin,X.,Wu,Y.,Wang,X.,Yang,F.,and Han,C.* (2013)Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-transcriptional Regulatory Mechanisms of Mouse Spermatogenesis,Mol Cell Proteomics 12,1144-1157.
Hou,X.,Zhang,W.,Xiao,Z.,Gan,H.,Lin,X.,Liao,S.,and Han,C.* (2012)Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis,BMC Genomics 13,495.
Zhang,Y.,Wang,S.,Wang,X.,Liao,S.,Wu,Y.,and Han,C.* (2012)Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells,Cell Research 22,773-776.
Gan,H.,Lin,X.,Zhang,Z.,Zhang,W.,Liao,S.,Wang,L.,and Han,C.* (2011)piRNA profiling during specific stages of mouse spermatogenesis,RNA 17,1191-1203.
Zhuang,X.J.,Hou,X.J.,Liao,S.Y.,Wang,X.X.,Cooke,H.J.,Zhang,M.,and Han,C.* (2011)SLXL1,a novel acrosomal protein,interacts with DKKL1 and is involved in fertilization in mice,PLoS One 6,e20866.
Shi,Y.Q.,Liao,S.Y.,Zhuang,X.J.,and Han,C.S.* (2011)Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37,Gene 485,153-159.
Liu,Z.,Lin,X.,Cai,Z.,Zhang,Z.,Han,C.,Jia,S.,Meng,A.,and Wang,Q.(2011)Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas,The Journal of biological chemistry 286,28520-28532.
Liu,H.,Wang,B.,and Han,C.* (2011)Meta-analysis of genome-wide and replication association studies on prostate cancer,The Prostate 71,209-224.
Yang,Y.,and Han,C.* (2010)GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway,BMC cell biology 11,78.
Shi,Y.Q.,Li,Y.C.,Hu,X.Q.,Liu,T.,Liao,S.Y.,Guo,J.,Huang,L.,Hu,Z.Y.,Tang,A.Y.,Lee,K.F.,Yeung,W.S.,Han,C.S.*,and Liu,Y.X.(2009)Male germ cell-specific protein Trs4 binds to multiple proteins,BBRC 388,583-588.
Nian,H.,Zhang,W.,Shi,H.,Zhao,Q.,Xie,Q.,Liao,S.,Zhang,Y.,Zhang,Z.,Wang,C.,and Han,C.* (2008)Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase,Cell research 18,800-802.
Zhang,K.,Shang,Y.,Liao,S.,Zhang,W.,Nian,H.,Liu,Y.,Chen,Q.,and Han,C.* (2007)Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis,BBRC 360,327-332.
Nian,H.,Fan,C.,Liao,S.,Shi,Y.,Zhang,K.,Liu,Y.,and Han,C.* (2007)RNF151,a testis-specific RING finger protein,interacts with dysbindin,Archives of biochemistry and biophysics 465,157-163.
Shi,Y.Q.,Wang,Q.Z.,Liao,S.Y.,Zhang,Y.,Liu,Y.X.,and Han,C.S.* (2006)In vitro propagation of spermatogonial stem cells from KM mice,Front Biosci 11,2614-2622.
Walke,D.W.,Han,C.,Shaw,J.,Wann,E.,Zambrowicz,B.,and Sands,A.(2001)In vivo drug target discovery:identifying the best targets from the genome,Current opinion in biotechnology 12,626-631.
Han,C.S.*,Chen,Y.,Ezashi,T.,and Roberts,R.M.(2001)Antiviral activities of the soluble extracellular domains of type I interferon receptors,PNAS 98,6138-6143.
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