2021年考研福建医科大学神经科学研究院徐丹课题组招收调剂研究生的通知

　　福建医科大学神经科学研究院 福建省分子病学重点实验室 徐丹副研究员招收生物学专业调剂生一名。欢迎优秀考生报考，如有兴趣请邮件咨询，联系方式：徐师， Email: xu200828@163.com。

　　导师简介：

　　徐丹, 博士, 副研究员，硕士生导师

　　2007年本科毕业于西北大学生命科学与技术基地班， 2010年西北大学获细胞生物学硕士，2015年在中国科学院遗传与发育生物学研究所获细胞生物学博士。2015年福州大学生物科学与工程学院生命科学研究所助理研究员，2020福建医科大学神经科学研究院副研究员。在国内外主流学术杂志发表论文20篇，其中第一作者/通讯作者（含共同）11篇。曾获得中国科学院地奥奖学金、益海嘉里优秀博士生奖、恒源英才奖等多个奖项；2019年获福州大学青年教师励志奖。目前作为遗传杂志审稿人、国家自然科学基金函评专家。

　　主要研究方向

　　主要从事神经发育疾病及其病理机制的研究。该实验室主要利用子宫内胚胎电转技术（IUE）研究新脑皮层发育过程中神经前体细胞的增殖、分化及神经院的迁移过程。同时利用时空特异性敲除策略分析基因敲除小鼠的生长发育过程及行为学特征来进一步研究神经发育疾病的病理机制。

　　发表论文：

　　1. Zhou, X.K, Zhi, Y.Q., Yu, J.R., Xu, D*. (2020). The Yin and Yang of Autosomal Recessive Primary Microcephaly Genes: Insights from Neurogenesis and Carcinogenesis. Int. J. Mol. Sci. 21(5), 1691.

　　2. Zhang, M., Fu, Z., Li, C., Liu, A., Peng, D., Xue, F., He, W., Gao, S., Xu, F., Xu, D., et al. (2019). Fast Super-Resolution Imaging Technique and Immediate Early Nanostructure Capturing by a Photoconvertible Fluorescent Protein. Nano letters.

　　3. Xu, D.*, Li, C., Qin, C.F. *, Xu, Z.H*. (2019). Update on the Animal Models and Underlying Mechanisms for ZIKV-Induced Microcephaly. Annual review of virology, 6, 13.1–13.21.

　　4. Xu, D.#, Yao M.#, Wang, Y.#, Yuan, L.#, Hoeck, J.#, Yu, J., Liu L., Yeap, Y., Zhang, F., Feng, Y., et al. (2018). MEKK3 Coordinates with FBW7 to Regulate WDR62 Stability and Neurogenesis. Plos biology, 16(2).

　　5. Li, C., Wang, Q., Jiang, Y., Ye, Q., Xu, D., Gao, F., Xu, J.W., Wang, R., Zhu, X., Shi, L., et al. (2018). Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice. Cell discovery 4, 43.

　　6. Xu, D.*, Zhu, Y.G., Xu, Z.H.*. (2017) Efficient genetic manipulation in the developing brain of tree shrew using in utero electroporation and virus infection. Journal of Genetics and Genomics 44 (10), 507-509. ( *corresponding author)

　　7. Yoon, K.J., Song, G., Qian, X., Pan, J., Xu, D., Rho, H.S., Kim, N.S., Habela, C., Zheng, L., Jacob, F., et al. (2017). Zika-virus-encoded NS2A disrupts mammalian cortical neurogenesis by degrading adherens junction proteins. Cell Stem Cell 21(3), 349-358.

　　8. Li, C. #, Xu, D. #,Ye, Q. #, Hong, S. #, Jiang Y.S., Liu, X.Y., Zhang, N.N., Shi, L., Qin, C.F., Xu, Z.H. (2016). Zika virus disrupts neural progenitor development and leads to microcephaly in mice. Cell Stem Cell 19, 120-126.( #co-first)

　　9. Zhang, F., Yu, J., Yang, T., Xu, D., Chi, Z., Xia, Y., and Xu, Z.H. (2016). A novel c-Jun N-terminal kinase (JNK) signaling complex involved in neuronal migration during brain development. Journal of Biological Chemistry 291, 11466-11475.

　　10. Xu, D., and Xu, Z.H. (2016). Driving WDR62 to the pole. Cell Cycle 15, 1180-1181.

　　11. Xu, D., Zhang, F., Wang, Y.Q., Sun, Y.M., and Xu, Z.H. (2014). Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Cell Reports 6, 104-116.

　　12. Zhang, F., Xu, D., Yuan L., Sun, Y.M., and Xu, Z.H. (2014). Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance. Nature Communications 5, 5815.

　　13. Lim, N.R., Yeap, Y.Y., Zhao, T.T., Yip, Y.Y., Wong, S.C., Xu, D., Ang, C.S., Williamson, N.A., Xu, Z., Bogoyevitch, M.A., et al. (2014). Opposing roles for JNK and Aurora A in regulating WD40-Repeat Protein 62 association with spindle microtubules. Journal of Cell Science 128, 527-540.

　　14. Du, Z.#, Xu, D. #, Li, L., Shi, Y., Schlappi, M., and Xu, Z.Q. (2012). Inhibitory effects of Arabidopsis EARLI1 against Botrytis cinerea and Bradysia difformis. Plant Cell, Tissue and Organ Culture 110, 435-443. (#co-first)

　　15. Li, L., Zhang, C., Xu, D., Schlappi, M., and Xu, Z.Q. (2012). Expression of recombinant EARLI1, a hybrid proline-rich protein of Arabidopsis, in Escherichia coli and its inhibition effect to the growth of fungal pathogens and Saccharomyces cerevisiae. Gene 506, 50-61. (IF= 2.196)

　　16. Xu, D., Huang, X., Xu, Z.Q., and Schlappi, M. (2011). The HyPRP gene EARLI1 has an auxiliary role for germinability and early seedling development under low temperature and salt stress conditions in Arabidopsis thaliana. Planta 234, 565-577.

　　17. Xu, Z.Q., Huang, X.A., Feng, C., Tian, N., Xu, D., and Feng, S.Z. (2010). Multicellular genesis of leaf primordium was demonstrated via chimaeric transgenic plant of maize (Zea mays L.) regenerated from Type II calli. Molecular Biology Reports 37, 3525-3531.

　　18. Chen, L.Y., Chen, Q.L., Xu, D., Hao, J.G., Schlappi, M., and Xu, Z.Q. (2009). Changes of gentiopicroside synthesis during somatic embryogenesis in Gentiana macrophylla. Planta Medica 75, 1618-1624.

　　19. 王玉杰，周小坤，徐丹 (2019).  常染色体隐性遗传小头畸形致病机制解析. 遗传10.

　　20. 徐丹，陈立余，徐子勤 (2009). 甜高粱离体再生体系的建立和组织结构变化的观察. 植物生理学通讯 45, 771-774