东华理工大学化学生物与材料科学学院导师介绍：陈焕文

　　陈焕文

　　性别：男

　　出生年月：1973年12月

　　职称职务：东华理工大学教授；江西省质谱科学与仪器重点实验室主任

　　研究方向：质谱分析

　　工作简历

　　1991年9月-1995年6月：赣南师范学院化学系，获学士学位。

　　1995年9月-1998年6月：东华理工大学应用化学系，师从张燮教授，获硕士学位。

　　1998年9月-2001年6月：吉林大学化学系，师从金钦汉教授，主要从事微型分析仪器研制和现场光度分析等研究。获博士学位。

　　2001年7月-2002年12月：吉林大学化学院，讲师。

　　2003年1月-2005年12月：在美国Purdue大学Aston质谱实验室进行博士后研究，师从Cooks教授。主要从事小型化质谱仪器的研制及应用研究。

　　2006年4月－2008年6月期间，多次赴瑞士联邦工学院（ETH）Zenobi教授课题组进行短期合作研究。

　　2006年1月至今，东华理工大学，教授。

　　研究兴趣

　　涉及分析化学与物理化学领域。主要包括新兴质谱技术的研发及其在复杂基体样品快速质谱分析中的应用研究，并注重通常条件下离子-分子，分子-分子相互作用的基础研究，以期发展能够用于实时、原位、活体、无损、快速的表征与检测的质谱学新方法。

　　经费来源

　　主要依靠国家自然科学基金委、科技部、江西省科技厅等部门的项目支持。

　　主要获奖情况

　　2010年获“江西省自然科学奖”一等奖，第一完成人。

　　部分近期论文

　　1． Xue Li, Bin Hu, Jianhua Ding, Huanwen Chen*． Rapid characterization of complex viscous samples at molecular levels by neutral desorption extractive electrospray ionization mass spectrometry． Nat． Protoc．, 2011,6(7):1010–1025

　　2． Huanwen Chen*, Renato Zenobi*, Neutral desorption sampling of biological surfaces for rapid chemical characterization by extractive electrospray ionization mass spectrometry, Nat． Protoc．, 2008, 3(9): 1467-1475

　　3． Huanwen Chen*, Shuiping Yang, Ming Li, Bin Hu, Jianqiang Li, Jiang Wang, Sensitive detection of native proteins using extractive electrospray ionization mass spectrometry, Angew． Chem． Int． Ed．, 2010,49(17):3053- 3056 Inside Cover Paper．

　　4． Konstantin Chingin, Vladimir Frankevich, Roman M． Balabin, Konstantin Barylyuk, Huanwen Chen, Rui Wang, Renato Zenobi*, Direct access to isolated biomolecules under ambient conditions, Angew． Chem． Int． Ed．, 2010,49(13): 2358-2361． Hot paper, Inside Cover Paper．

　　5． Wai Siang Law, Huanwen Chen*, Jianhua Ding, Shuiping Yang, Liang Zhu, Gerardo Gamez, Konstantin Chingin, Yulin Ren, Renato Zenobi*, Rapid characterization of complex viscous liquids at the molecular level, Angew． Chem． Int． Ed．, 2009,48(44):8277-8280

　　6． Huanwen Chen*, Shuiping Yang, Arno Wortmann, Renato Zenobi*, Neutral desorption sampling of living objects for rapid analysis by extractive electrospray ionization mass spectrometry, Angew． Chem． Int． Ed．, 2007, 46(40): 7591-7594． VIP paper, Highlighted in Nature

　　7． Huanwen Chen, Arno Wortmann, Weihua Zhang, Renato Zenobi*, Rapid in vivo fingerprinting of nonvolatile compounds in breath by extractive electrospray ionization quadrupole time-of-flight mass spectrometry, Angew． Chem． Int． Ed．, 2007, 46(4): 580-583． Inside Cover Paper, VIP, Hot Paper．

　　8． Bin Hu, Pui-Kin So, Huanwen Chen*, Zhong-Ping Yao*． Electrospray Ionization Using Wooden Tips． Anal． Chem．, 2011,83 (21):8201–8207

　　9． Wai Siang Law, Rui Wang, Bin Hu, Christian Berchtold, Lukas Meier, Huanwen Chen*, Renato Zenobi*, On the Mechanism of Extractive Electrospray Ionization, Anal． Chem．, 2010,82(11):4494-4500

　　10． Xinglei Zhang, Bin Jia, Bin Hu, Rong Chen, Huanwen Chen*, Tracing Origins of Complex Pharmaceutical Preparations Using Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry, Anal． Chem．, 2010,82(19):8060-8070

　　11． Mingbiao Luo, Bin Hu, Xie Zhang, Daofeng Peng, Huanwen Chen*, Lili Zhang, Yanfu Huan, Extractive electrospray ionization mass spectrometry for sensitive detection of uranyl species in natural water samples, Anal． Chem．, 2010, 82(1): 282-289．

　　12． Jianhua Ding, Haiwei Gu, Shuiping Yang, Ming Li, Jianqiang Li, Huanwen Chen*, Selective detection of diethylene glycol in toothpaste products using neutral desorption reactive extractive electrospray ionization tandem mass spectrometry, Anal． Chem．, 2009, 81(20): 8632-8638．

　　13． Ming Li, Bin Hu, Jianquiang Li, Rong Chen, Xie Zhang, Huanwen Chen*, Extractive electrospray ionization mass spectrometry towards in situ analysis without sample pretreatment, Anal． Chem．, 2009, 81(18): 7724-7731．

　　14． Shuiping Yang, Jing Han, Xie Zhang, Yanfu Huan, Yanjuan Cui, Xie Zhang, Huanwen Chen*, Haiwei Gu*, Desorption electrospray ionization tandem mass spectrometry for detection of 24 carcinogenic aromatic amines in textiles, Anal． Chem．, 2009, 81(15): 6070-6079．

　　15． Konstantin Chingin, Huanwen Chen*, Gerardo Gamez, Liang Zhu, Renato Zenobi*, Detection of diethyl phthalate in perfumes by extractive electrospray ionization mass spectrometry, Anal． Chem．, 2009, 81(6): 2414．

　　16． Konstantin Chingin, Huanwen Chen*, Gerardo Gamez, Liang Zhu, Renato Zenobi*, Detection of diethyl phthalate in perfumes by extractive electrospray ionization mass spectrometry, Anal． Chem．, 2009, 81(1): 123-129．

　　17． Shuiping Yang, Jianhua Ding, Jian Zheng, Bin Hu, Jianqiang Li, Huanwen Chen*, Zhiquan Zhou, Xiaolin Qiao, Detection of melamine in milk products by surface desorption atmospheric pressure chemical ionization mass spectrometry, Anal． Chem．, 2009, 81(7): 2426-2436． Accelerated paper． Most Cited Paper．

　　18． Huanwen Chen, Yanping Sun, Arno Wortmann, Haiwei Gu, and Renato Zenobi*, Differentiation of maturity and quality of fruit using noninvasive extractive electrospray ionization quadrupole time-of-flight mass spectrometry, Anal． Chem．, 2007, 79(4): 1447-1455．

　　19． Haiwei Gu, Huanwen Chen, Zhengzheng Pan, Ayanna U． Jackson, Nari Talaty, Bowei Xi, Candice Kissinger, Chester Duda, Doug Mann, Daniel Raftery*, R． Graham Cooks*, Monitoring diet effects via biofluids and their implications for metabolomics studies, Anal． Chem．, 2007; 79(1): 89-97． Most-cited Paper．

　　20． Huanwen Chen, Nari Talaty, Zoltan Takats, R Graham Cooks*, Desorption electrospray ionization mass spectrometry for high-throughput analysis of pharmaceutical samples in the ambient enviroment, Anal． Chem．, 2005, 77(21): 6915-6927． Most-cited Paper．

　　21． Ismael Cotte-Rodrίguez, Zoltán Takáts, Nari Tataly, Huanwen Chen, R． Graham Cooks*, Desorption electrospray ionization of explosives on surfaces: sensitivity and selectivity enhancement by reactive desorption electrospray ionization, Anal． Chem．, 2005, 77(21): 6755-6764． Accelerated paper

　　22． Gerardo Gamez, Liang Zhu, Andreas Disko, Huanwen Chen, Vladimir Azov, Konstantin Chingin, Günter Krämer and Renato Zenobi． "Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath"． Chem． Commun．, 2011,47(17):4884-4886

　　23． Liang Zhu, Gerardo Gamez, Huanwen Chen*, Konstantin Chingin, Renato Zenobi*, Rapid detection of melamine in untreated milk and wheat gluten by ultrasound-assisted extractive electrospray ionization mass spectrometry (EESI-MS), Chem． Commun．, 2009, (5): 559-561．

　　24． Huanwen Chen, Andre Venter and R． Graham Cooks*, Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation． Chem． Commun．, 2006, 19, 2042-2044．

　　25． Zoltán Takáts, Ismael Cotte-Rodriguez, Nari Talaty, Huanwen Chen, R． Graham Cooks*, Direct, trace level detection of explosives on ambient surfaces by desorption electrospray ionization mass spectrometry, Chem． Commun．, 2005, 15:1950-1952． Cover paper

　　26． Bin Hu, Xuejiao Peng, Shuiping Yang, Haiwei Gu, Huanwen Chen*, Yanfu Huan, Tingting Zhang, Xiaolin Qiao, Fast quantitative detection of Cocaine in beverages using nanoextractive electrospray ionization tandem mass spectrometry, J． Am． Soc． Mass Spectrom．, 2010, 21(2): 290-293

　　27． Huanwen Chen, Gerardo Gamez, Renato Zenobi*, What can we learn from ambient ionization techniques? J． Am． Soc． Mass Spectrom．, 2009, 20(11): 1947-1963．

　　28． Huanwen Chen*, Bin Hu, Yan Hu, Yanfu Huan, Zhiquan Zhou, Xiaolin Qiao, Neutral desorption using a sealed enclosure to sample explosives on human skin for rapid detection by EESI-MS, J． Am． Soc． Mass Spectrom．, 2009, 20(4): 719-722． Cover Paper

　　29． Hao Chen, Huanwen Chen, R． Graham Cooks*, Meisenheimer complexes bonded at carbon and at oxygen, J． Am． Soc． Mass Spectrom．, 2004, 15(7): 998-1004．

　　30． Hao Chen, Huanwen Chen, R． Graham Cooks*, Habib Baghen． Generation of arylnitrenium ions by nitro-reduction and gas-phase synthesis of N-Heterocycles, J． Am． Soc． Mass Spectrom．, 2004, 15(11): 1675-1688．

　　31． Yan Liu, Xinglei Zhang, Yongzhong Ouyang, Zhong Hu, Ma Li, Jinghua Zhang, Jinming Lin and Huanwen Chen*． Trace detection of hormones and sulfonamides in viscous cosmetic products by neutral desorption extractive electrospray ionization tandemmass spectrometry． J． Mass Spectrom．, 2011,46（8）:794-803

　　32． Bin Jia, Yongzhong Ouyang, Rana N． S． Sodhi, Bin Hu, Tingting Zhang, Jianqiang Li, Huanwen Chen*． Differentiation of human kidney stones induced by melamine and uric acid using surface desorption atmospheric pressure chemical ionization mass spectrometry． J． Mass Spectrom．, 2011,46(3):313-319

　　33． Huanwen Chen, Arno Wortmann, Renato Zenobi*, Neutral desorption sampling coupled to extractive electrospray ionization mass spectrometry for rapid differentiation of biosamples by metabolomic fingerprinting． J． Mass Spectrom．, 2007, 42(9): 1123-1135．

　　34． Huanwen Chen*, Jian Zheng , Xie Zhang , Mingbiao Luo , Zhichang Wang , Xiaolin Qiao*, Surface desorption atmospheric pressure chemical ionization mass spectrometry for direct ambient sample analysis without toxic chemical contamination． J． Mass Spectrom．, 2007, 42(8): 1045-1056．

　　35． Huanwen Chen, Ruifeng Xu, Hao Chen, R． Graham Cooks*, Zheng Ouyang, Ion/molecule reactions in a miniature RIT mass spectrometer, J． Mass Spectrom．, 2005, 40(11): 1403-1411．

　　36． Bin Hu, Xinglei Zhang, Ming Li*, Xuejiao Peng, Jing Han, Shuiping Yang, Yongzhong Ouyang and Huanwen Chen*． Coupling corona discharge for ambient extractive ionization mass spectrometry． Analyst, 2011,136 (23):4977 – 4985

　　37． Bin Hu, Shuiping Yang, Ming Li, Haiwei Gu, Huanwen Chen*． Direct detection of native proteins in biological matrices using extractive electrospray ionization mass spectrometry． Analyst, 2011,136(18):3599-3601

　　38． Haiwei Gu, Shuiping Yang, Jianqiang Li, Bin Hu, Huanwen Chen*, Lili Zhang, Qiang Fei, Geometry-independent neutral desorption device for the sensitive EESI-MS detection of explosives on various surfaces, Analyst, 2010, 135(4):779-788

　　39． Haiwei Gu, Bin Hu, Jianqiang Li, Shuiping Yang, Jing Han, Huanwen Chen*, Rapid analysis of aerosol drug products using nano extractive electrospray ionization tandem mass spectrometry, Analyst,2010,135(6):1259-1267

　　40． Jianhua Ding, Shuiping Yang, Dapeng Liang, Huanwen Chen*, Zhuanzhang Wu, Lili Zhang, Yulin Ren*, Development of extractive electrospray ionization ion trap mass spectrometry for in vivo breath analysis, Analyst, 2009, 134(10): 2040-2050．

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