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中药大生命科学与技术学院导师介绍:窦洁


  窦洁,女,1971年出生,中国药科大学微生物教研室 副教授
  长期从事微生物学和免疫学的教学和研究工作。研究工作集中在抗病毒药物药效与机制研究、病毒免疫、微生物代谢调控等领域。并担任“江苏省微生物学会病毒专业委员会”委员、“江苏省预防接种异常反应鉴定专家库”成员、“江苏省免疫学会第三届理事会”理事。

  主要经历
  1997.9—至今  中国药科大学微生物学教研室 教师
  2001.9—2005.6  南京医科大学基础医学院免疫学专业 博士

  主要论著
  (1) Kai Chen, Jie Dou, Shirui Tang, Yishun Yang, Hui Wang, Hongqing Fang, Changlin Zhou. Deletion of the aroK gene is essential for high shikimic acid accumulation through the shikimate pathway in E. coli. Bioresource Technology, 2012 May 29; 119C: 141-147. [Epub ahead of print] (IF4.98)
  (2)   Zhenzhen Su, Jie Dou, Zhipeng Xu, Qinglong Guo, Changlin Zhou. A novel inhibitory mechanism of baicalein on influenza A/FM1/1/47 (H1N1) virus: interference with mid-late mRNAs synthesis in cell culture. Chinese Journal of Natural Medicines. Accept, 25-Apr-2012 (SCIE)
  (3) Lili Chen, Jie Dou1, Zhenzhen Su, Huimin Zhou, Hui Wang, Weidong Zhou, Qinglong Guo,ChanglinZhou.  Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice.Antiviral Research,2011, 91(3): 314-320. (IF 4.439)
  (4) Huimin Zhou, Jie Dou1, Jing Wang, Lili Chen, Hui Wang, Weidong Zhou, Yunman Li, Changlin Zhou. The antibacterial activity of BF-30 in vitro and in infected burned rats is through interference with cytoplasmic membrane integrity. Peptides. 2011,32(6): 1131-1138. (IF 2.705)
  (5) 周慧敏,陈莉莉,王晶,窦洁,王慧等。金环蛇抗菌肽Cathelicidin-BF的体外抗菌活性研究. 药物生物技术, 2011, 18(4)。
  (6) Wei Chen, Baowei Yang, Huimin Zhou, Lidan Sun, Jie Dou, Hai Qian, Wenlong Huang, Yicheng Mei, Jing Han. Structure-activity relationships of a snake cathelicidin-related peptide, BF-15. Peptide., 2011, Oct 8;: 22008732. (IF 2.705)
  (7) Hui Wang, Mengyu Wang, Jing Chen, Ying Tang, Jie Dou, Jian Yu, Tao Xi,ChanglinZhou. A polysaccharide fromStrongylocentrotus nuduseggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated mice. International Immunopharmacology,2011, 11(11):1946-1953.
  (8) Mengyu Wang, Hui Wang, Ying Tang, Di Kang, Yu Gao, Mengyun Ke, Jie Dou, Tao Xi,ChanglinZhou. Effective inhibition of aStrongylocentrotus nuduseggs polysaccharide against hepatocellular carcinoma is mediated via immunoregulationin vivo. Immunology Letters,2011,141(1): 74-82.
  (9) Jie Dou, Lili Chen, Ge Xu, Lei Zhang, Huimin Zhou, Hui Wang, Zhenzhen Su, Mengyun Ke, Qinglong Guo, Changlin Zhou.  Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin-neuraminidase. Arch Virol., 2011, 156 (5):793-801.(IF 2.209)
  (10) Ge Xu, Jie Dou1, Lei Zhang, Lei Zhang, Qinglong Guo, Changlin Zhou. Inhibitory Effects of Baicalein on the Influenza Virus in Vivo Is Determined by Baicalin in the Serum. Biol. Pharm. Bull., 2010, 33(2): 238-243. (IF 1.811)
  (11) 张磊,李孟秋,窦洁,吴玉林,周长林。金蝉口服液体内外抗流感病毒活性的研究。药物生物技术,2009,16(5):439-443。
  (12) 窦洁,苏宝亮,张磊,许戈,赵德育,周长林。呼吸道合胞病毒SH蛋白免疫原性初步研究。苏州大学学报医学版,2009,29(6):22-25。
  (13) 陈松洪秀娟黄雷鸣窦洁周长林。好氧反硝化细菌N6-1亚硝酸盐还原活性的研究。微生物学通报,2008,35(7):1007-1010。
  (14) 彭蕴茹,窦洁,黄芳,钱大玮。复方野马追胶囊抗流感病毒实验研究。中成药,2008,30(5):650-654。
  (15) 彭蕴茹,窦洁,黄芳,钱大玮。复方野马追胶囊的体内抑菌抗病毒实验研究。时珍国医国药,2008,19(3):542-544。
  (16) 李孟秋,窦洁,杜伟,李新亚,林健。雷公藤红素对小鼠的免疫抑制作用及其对IL-6mRNA表达的研究。中国临床药理学与治疗学杂志,2008,13(2):158-163。
  (17) 窦洁,李孟秋,陈松万文军李新亚林健周长林。雷公藤甲素对小鼠免疫功能的抑制作用。药物生物技术,2007, 14(6): 429~431。
  (18) XU Jian, YAO Kun, DOU Jie, QIN Jian, XU Wen-Rong, CHEN Yun, YIN Quan-Zhang, ZHOU Feng.  Human Herpesvirus 7 Glycoprotein B (gB) , gH, gL, gO Can Mediate Cell Fusion.  PROG BIOCHEM BIOPHYS, 2007,34(11):1202-1209.
  (19) 徐建,姚堃,窦洁,许文嵘,尹全章,陈云,周锋。人疱疹病毒7型pp85重组表达及抗体制备。微生物与感染,2007,2(2):88-91。


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